Each dose of Fioricet contains 300 to 325 mg of acetaminophen. Many other medications also contain acetaminophen. Your upper daily limit from all sources is 3,000 mg per day. Taking too much acetaminophen (found in this combination preparation) can cause liver damage, sometimes serious enough to require liver transplantation or cause death. Be aware that … Read more
Fioricet can interact with other medications. Before taking Fioricet, it’s important to review your medications with your doctor or pharmacist. Make sure to mention both prescription and nonprescription medications and supplements. The following types of medication are known to interact with Fioricet: monoamine oxidase (MAO) inhibitors general anesthetics opioids (also known as narcotics) such as … Read more
Fioricet contains three compounds. Each has a different action to help manage pain: Butalbital: This compound is a type of barbiturate. It reduces anxiety and causes drowsiness by relaxing your muscles and nervous system. As it can be habit-forming, medications with butalbital are tightly regulated. Acetaminophen: This is a widely used medication to reduce pain … Read more
Acetaminophen, butalbital, and caffeine is used to relieve tension headaches. Acetaminophen is in a class of medications called analgesics (pain relievers). It works by changing the way the body senses pain. Butalbital is in a class of medications called barbiturates. It works by having a relaxing effect on the brain and central nervous system (CNS). … Read more
Chlorpheniramine; Pseudoephedrine: (Moderate) Additive CNS depression may occur if barbiturates are co-used with sedating antihistamines, such as chlorpheniramine. Monitor for additive CNS and respiratory effects, and warn about the potential effects to driving and other activities. (Moderate) CNS-stimulating actions of caffeine can be additive with other CNS stimulants or psychostimulants; caffeine should be avoided or … Read more
Chlordiazepoxide; Amitriptyline: (Moderate) Additive CNS and/or respiratory depression may occur. Additionally, barbiturates may increase the metabolism of chlordiazepoxide. Chlordiazepoxide is a CYP3A4 substrate. Barbiturates are CYP3A4 inducers. Chlordiazepoxide; Clidinium: (Moderate) Additive CNS and/or respiratory depression may occur. Additionally, barbiturates may increase the metabolism of chlordiazepoxide. Chlordiazepoxide is a CYP3A4 substrate. Barbiturates are CYP3A4 inducers. Chloroprocaine: … Read more
Carbinoxamine: (Moderate) Additive CNS depression may occur if barbiturates are co-used with sedating antihistamines, such as carbinoxamine. Monitor for additive CNS and respiratory effects, and warn about the potential effects to driving and other activities. Cardiac glycosides: (Moderate) Hepatic enzyme inducing drugs, such as barbiturates, can accelerate the metabolism of digoxin, decreasing its serum concentrations. … Read more
Bupropion: (Moderate) Bupropion is associated with a dose-related risk of seizures. Excessive use of psychostimulants, including caffeine, is associated with an increased seizure risk and may increase this risk during the concurrent use of bupropion. Carefully consider a patient’s caffeine intake from all sources, including medicines. Monitor for irritability, tremor, increased blood pressure, insomnia and … Read more
Abacavir; Lamivudine, 3TC; Zidovudine, ZDV: (Minor) Both acetaminophen and zidovudine, ZDV undergo glucuronidation. Competition for the metabolic pathway is thought to have caused a case of acetaminophen-related hepatotoxicity. This interaction may be more clinically significant in patients with depleted glutathione stores, such as patients with acquired immunodeficiency syndrome, poor nutrition, or alcoholism. Abemaciclib: (Major) Avoid … Read more
Common side effects of Butalbital/Acetaminophen/Caffeine include: drowsiness, dizziness, feeling “drunk”, headache, tiredness, nausea, vomiting, stomach pain, and constipation Serious side effects of Butalbital/Acetaminophen/Caffeine include: hives, difficulty breathing, swelling of the face, lips, tongue, or throat, skin redness, rash that spreads and causes blistering and peeling, slow breathing with long pauses, blue colored lips, difficult to … Read more